血管緊張素Ⅱ?qū)Υ笫笠葝uβ細胞形態(tài)功能的影響

作者：劉萍，何嵐，王毅，李建寧，葉楓，劉治全
【關鍵詞】 血管緊張素Ⅱ；鹽；胰島β細胞；高血壓;大鼠
　　Effects of angiotensin II on morphology and function of islets βcells in rats
　　【Abstract】 AIM: To study the effects of angiotensin II (AngⅡ) on the function and morphology of islets βcells. METHODS: The SD rats accepted AngⅡ by hypodermic injection with the osmotic minipump for 2 weeks. Hereafter, they were fed with a normal (8 g/L NaCl) or highsalt (40 g/L NaCl) diet respectively. The following indexes, including blood pressure, fasting blood glucose, insulin and the morphology of islets βcells were observed. RESULTS: The blood pressure of rats was significantly elevated 2 weeks after accepting AngⅡ via chronic hypodermic injection; at the end of 4 weeks, compared with control group, the blood pressure was increased unceasingly and markedly in the rat with AngⅡ infusions; meanwhile, the areas of islets βcells in the rats of highsalt diet became larger than those of control group (P

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